Management Team

Brian H. Johnston, Ph.D., Founder and Chief Executive Officer
Dr. Johnston has over 30 years of experience in scientific innovation and product development. He holds a Ph.D. in biophysical chemistry from the University of California, Berkeley and did post-doctoral research at UCSF and MIT. Dr. Johnston was previously Director of the Nucleic Acids Program at SRI International and Consulting Professor of Pediatrics at Stanford University School of Medicine.  He has coauthored 55 scientific papers and 18 patents.

Sergei A. Kazakov, Ph.D., Vice President for Discovery Research
Dr. Kazakov has over 25 years of research experience and is a recognized authority in nucleic acid chemistry. He received his Ph.D. in bioorganic chemistry from Moscow State University and did post-doctoral research at Yale University. Dr. Kazakov has also been a research scientist at the University of Virginia. He is the author of 43 scientific papers and 12 patents.

Charlotte Clark, MBA, Chief Business Officer
Ms. Clark has 25 years experience in the areas of finance and business development in life science companies. She has been a co-founder of four companies and has served as a senior operating executive in companies involved in pharmaceuticals, drug delivery and gene therapy. Most recently, she was a Managing Member of POSCO BioVentures, a venture capital company that invested in 21 portfolio companies. One portfolio company was acquired, and 5 went public during her tenure. Ms. Clark served on the Board of Directors of two portfolio companies, and was an observer to the Board for three more companies. She has a BA from the University of Virginia and an MBA from the Anderson school at UCLA.

Scientific Advisors (partial list)

John J. Rossi, Ph.D.
Professor and Dean of the Graduate School, Beckman Research Institute of the City of Hope National Medical Center. Dr. Rossi is a pioneer in the therapeutic use of ribozymes and siRNAs against HIV and a prominent researcher in the biology of RNAi.  He has been awarded the prestigious MERIT Award for the Division of AIDS at the National Institute of Allergy and Infectious Diseases (NIAID).

Patricia P. Jones, Ph.D.
Professor and former Chair of the Department of Biological Sciences, Stanford University. Dr. Jones studies the genetic, cellular, and molecular mechanisms that regulate adaptive and innate immune responses.

Harvey J. Cohen, M.D., Ph.D.
Professor and former Chairman, Department of Pediatrics, Stanford University School of Medicine and Chief of Staff, Lucile Packard Children's Hospital. A clinician and researcher in hematology and oncology, Dr. Cohen has studied the cellular biology and biochemistry of granulocyte function especially as they relate to the oxidative killing ability of phagocytic cells.

Gerald. G. Krueger, M.D.
Professor of Dermatology, University of Utah School of Medicine.  A recognized authority on psoriasis, Dr. Krueger has led many key clinical trials of psoriatic drugs. He was the recipient of the Taub International Award for Psoriasis Research and a National Psoriasis Foundation Lifetime Achievement Award.