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RealSeq®-AC

RealSeq®-AC is a novel proprietary method for preparing small-RNA sequencing libraries that nearly eliminates incorporation bias in Next-Generation-Sequencing (NSG). Commonly used sequencing library preparations lead to underestimation of the abundance of most miRNAs, some by as much as 10,000-fold.

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Therapeutic sshRNAs

SomaGenics has pioneered the discovery and development of a unique class of short interfering RNAs called sshRNAs. Structurally distinct from the more commonly used siRNAs and expressed shRNAs, they are short, chemically modified RNA sequences that are synthesized as single strands. SshRNAs have outstanding potency and possess attractive pharmacokinetic properties without undesirable immune stimulation.

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RNA Detection

MicroRNAs (miRNAs) are of increasing interest as potential biomarkers and drug targets. The ability to accurately quantify them from biofluids such as blood, urine, or saliva ("liquid biopsy") is crucial to realizing their potential in early disease detection, diagnosis, drug development, and selecting and following treatment.

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miR-ID® microRNA Detection Platform

miR-ID® is a novel platform for detecting miRNA using a circularization-based RT-qPCR method.  miR-ID® is highly sensitive, uses single-dye detection, and can discriminate miRNA isoforms with single nucleotide differences at any position along the molecule.  The technology works well with all sample sources, including total RNA, cell lysates, and tissue lysates.

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Background sshRNA Technology

Somagenics’ synthetic short hairpin RNA (sshRNAs) can be highly potent RNAi effectors with activities similar to or more potent than the more commonly used siRNAs targeting the same sequences.

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